Fenbendazole (5-(phenylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester, sold under the brand names Pancur and Safe-Guard, is used worldwide as a broad-spectrum anthelmintic. It is known to kill parasites such as giardia, roundworms, hookworms, whipworms and tapeworms, and also treats liver and intestinal diseases. It is a very effective treatment for a number of parasitic infections in dogs, cats, livestock, birds and other animals.
It is also being investigated as a possible anti-cancer drug for humans, and it has been shown to prevent the formation of cancer cell tumors in mice models. It works by blocking the cancer cells ability to process sugar and thereby starves them of their primary energy source. It can be taken orally in the form of capsules. It has a wide margin of safety for humans. It has been used for many years in veterinary medicine to treat gastrointestinal parasites.
It has also been reported to prevent chemo-resistance by killing cancer cells and inhibiting a number of cellular pathways. It can be used alone or in combination with other agents such as radiation and chemotherapy. It has been shown to improve the cytotoxicity of radiation against EMT6 mammary carcinoma cells in culture and to prevent chemo-resistance in mice with multi-drug resistance xenografted tumors. In addition, it can significantly increase the cytotoxicity of multiple myeloma cancer cells in culture and in mice with xenografted disease and in vivo. It also increases the sensitivity of hypoxic cancer cells to radiation.sanare lab fenbendazole